Research Article
Insilico Analysis of Protein-Ligand Docking of DHFR ( Dihydro Folate Reductase) and Quassinoids
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International Journal of Computer Applications
Foundation of Computer Science (FCS), NY, USA
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| Volume 62 - Issue 12 |
| Published: January 2013 |
| Authors: R. D. Shailima Vardhini |
10.5120/10131-4919
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R. D. Shailima Vardhini . Insilico Analysis of Protein-Ligand Docking of DHFR ( Dihydro Folate Reductase) and Quassinoids. International Journal of Computer Applications. 62, 12 (January 2013), 14-19. DOI=10.5120/10131-4919
@article{ 10.5120/10131-4919,
author = { R. D. Shailima Vardhini },
title = { Insilico Analysis of Protein-Ligand Docking of DHFR ( Dihydro Folate Reductase) and Quassinoids },
journal = { International Journal of Computer Applications },
year = { 2013 },
volume = { 62 },
number = { 12 },
pages = { 14-19 },
doi = { 10.5120/10131-4919 },
publisher = { Foundation of Computer Science (FCS), NY, USA }
}
%0 Journal Article
%D 2013
%A R. D. Shailima Vardhini
%T Insilico Analysis of Protein-Ligand Docking of DHFR ( Dihydro Folate Reductase) and Quassinoids%T
%J International Journal of Computer Applications
%V 62
%N 12
%P 14-19
%R 10.5120/10131-4919
%I Foundation of Computer Science (FCS), NY, USA
Abstract
Quassinoids are the naturally available plant extracts which exhibit a wide range of biological activities , that include anti malarial, anti amoebic, anti tumor properties etc. The present experiment aims to exploit the antitumor properties of the quassinoids. 68 quassinoid analogues were designed and were docked with hDHFR (human dihydrofolate reductase) a potential cancer target. The docking results showed compound 33 to be the best ligand for DHFR.
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